loading...| Preferred Name |
Runt-Related Transcription Factor 1 |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18319 |
| code |
C18319 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 |
| Contributing_Source |
CTRP |
| DEFINITION |
Runt-related transcription factor 1 (453 aa, ~49 kDa) is encoded by the human RUNX1 gene. This protein is involved in the promotion of gene transcription and hematopoiesis. |
| DesignNote |
Part of the heterodimeric transcription factor Core-Binding Factor. The CBFalpha subunit binds directly to the enhancer core DNA sequence on target genes, whereas the beta subunit does not bind the DNA directly but increases the affinity and stabilizes the binding of the alpha subunit to the DNA. |
| Display_Name |
Runt-Related Transcription Factor 1 |
| FULL_SYN |
SL3-3 Enhancer Factor 1 Alpha B Subunit Core-Binding Factor Alpha B Subunit Runt-Related Transcription Factor 1 Core-Binding Factor, Runt Domain, Alpha Subunit 2 Core-Binding Factor Alpha CBFA2 AML1 Protein PEA2-Alpha B Oncogene AML-1 Acute Myeloid Leukemia 1 Protein PEBP2-Alpha B Acute Myeloid Leukemia-1 Protein Polyomavirus Enhancer-Binding Protein 2 Alpha B Subunit Core-Binding Factor Subunit Alpha-2 AML1 AML-1 CBF-Alpha B Polyomavirus Enhancer Binding Protein 2 Alpha B Subunit CBF-Alpha-2 RUNX1 Sl3/AKV Core-Binding Factor Alpha B Subunit AML-1 Protein SL3/AKV Core-Binding Factor Alpha B Subunit CBF-Alpha |
| label |
Runt-Related Transcription Factor 1 |
| Legacy Concept Name |
Core-Binding_Factor_Alpha |
| OMIM_Number |
151385 |
| Preferred_Name |
Runt-Related Transcription Factor 1 |
| prefixIRI |
Thesaurus:C18319 |
| prefLabel |
Runt-Related Transcription Factor 1 |
| Semantic_Type |
Amino Acid, Peptide, or Protein |
| Swiss_Prot |
Q01196 |
| UMLS_CUI |
C1435548 |
| subClassOf |