loading...| Preferred Name |
CX3C Chemokine Receptor 1 |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26209 |
| code |
C26209 |
| DEFINITION |
CX3C chemokine receptor 1 (355 aa, ~40 kDa) is encoded by the human CX3CR1 gene. This protein plays a role in cell adhesion, chemotaxis, cell defense response and signal transduction. |
| DesignNote |
Up-regulated by chronic inflammation and encoded by human CX3CR1 Gene (CCR Family, Rhodopsin Family), 355-amino acid 40.4-kD high-affinity Fractalkine Receptor is a seven transmembrane protein expressed in brain, peripheral blood leukocytes, and spleen as a regulator of leukocyte endothelial trafficking: chemotaxis, cell migration, and adhesion. CX3CR1 signals through a pertussis toxin sensitive G-protein to induce migration and contains common GPCR features. Tyrosine sulfation enhances fractalkine-induced cell adhesion. Sharing the CX3C motif, RSV G glycoprotein can use CX3CR1 as a receptor. CX3CR1 may be an HIV envelope protein co-receptor with CD4. Homozygous CX3CR1 I249/M280 haplotype enhances infection and progression to AIDS. (from LocusLink, Swiss-Prot, OMIM) |
| FULL_SYN |
CX3C Chemokine Receptor 1 V28 G-Protein Coupled Receptor Family 1 Fractalkine Receptor CX3CR1 CX3CR1 Protein CX3CR1 C-X3-C CKR-1 CMKBLR1 Chemokine (C-C) Receptor-Like 1 Beta Chemokine Receptor-Like 1 CMK-BRL-1 Chemokine, CX3C Motif, Receptor 1 Chemokine (C-X3-C Motif) Receptor 1 G-Protein Coupled Receptor 13 G Protein-Coupled Receptor V28 G Protein-Coupled Receptor 13 CMK-BRL1 Fractalkine Receptor |
| label |
CX3C Chemokine Receptor 1 |
| Legacy Concept Name |
Fractalkine_Receptor |
| OMIM_Number |
601470 |
| Preferred_Name |
CX3C Chemokine Receptor 1 |
| prefixIRI |
Thesaurus:C26209 |
| prefLabel |
CX3C Chemokine Receptor 1 |
| Semantic_Type |
Receptor Amino Acid, Peptide, or Protein |
| Swiss_Prot |
P49238 |
| UMLS_CUI |
C1143767 |
| subClassOf |