loading...| Preferred Name |
Toll-Like Receptor 4 |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C30105 |
| code |
C30105 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 |
| Contributing_Source |
CTRP |
| DEFINITION |
Toll-like receptor 4 (839 aa, ~96 kDa) is encoded by the human TLR4 gene. This protein is involved in regulation of both fatty acid-induced inflammation and the innate immune response following bacterial lipopolysaccharide binding. |
| DesignNote |
As part of the LPS receptor (with CD14 and LY96), TLR4 mediates the immune response to LPS in gram-negative bacteria. Binding to LY96 via the extracellular domain and to MyD88 and TIRAP via their TIR domains, TLR4 acts via MyD88, TIRAP, and TRAF6, leading to NF-kappa-B activation, cytokine secretion, and the inflammatory response. TLR4 Asn-526 and Asn-575 glycosylation seems necessary for the LPS-response. |
| Display_Name |
Toll-Like Receptor 4 |
| FULL_SYN |
CD284 Antigen hToll Toll-Like Receptor 4 TOLL Toll Homolog TLR4 |
| label |
Toll-Like Receptor 4 |
| Legacy Concept Name |
Toll-Like_Receptor-4 |
| OMIM_Number |
603030 |
| Preferred_Name |
Toll-Like Receptor 4 |
| prefixIRI |
Thesaurus:C30105 |
| prefLabel |
Toll-Like Receptor 4 |
| Semantic_Type |
Receptor Amino Acid, Peptide, or Protein |
| Swiss_Prot |
O00206 |
| UMLS_CUI |
C1321919 |
| subClassOf |