loading...| Preferred Name |
Heparin |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C539 |
| Accepted_Therapeutic_Use_For |
Conditions requiring anticoagulation (thrombosis; embolism) |
| ALT_DEFINITION |
A substance that slows the formation of blood clots. Heparin is made by the liver, lungs, and other tissues in the body and can also made in the laboratory. Heparin may be injected into muscle or blood to prevent or break up blood clots. It is a type of anticoagulant. Heparin is an indirect thrombin inhibitor composed of a mixture of heterogeneous mucopolysaccharides with a molecular weight of 5–30 kDa. |
| CAS_Registry |
9005-49-6 |
| CHEBI_ID |
CHEBI:28304 |
| Chemical_Formula |
(C14H18NO11)n.2(C12H16NO13S)n.3HO3S |
| code |
C539 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191671 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191387 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191200 |
| Contributing_Source |
ACC/AHA CTRP FDA |
| DEFINITION |
A sulfur-rich glycosaminoglycan with anticoagulant property. Heparin binds to antithrombin III to form a heparin-antithrombin III complex. The complex binds to and irreversibly inactivates thrombin and other activated clotting factors, such as factors IX, X, XI, and XII, thereby preventing the polymerization of fibrinogen to fibrin and the subsequent formation of clots. |
| Display_Name |
Heparin |
| FDA_UNII_Code |
T2410KM04A |
| FULL_SYN |
heparin Heparin HEPARIN Unfractionated heparin Unfractionated Heparin UFH |
| Has_Salt_Form |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1034 |
| label |
Heparin |
| Legacy Concept Name |
Heparin |
| NCI_Drug_Dictionary_ID |
40848 |
| PDQ_Closed_Trial_Search_ID |
40848 |
| PDQ_Open_Trial_Search_ID |
40848 |
| Preferred_Name |
Heparin |
| prefixIRI |
Thesaurus:C539 |
| prefLabel |
Heparin |
| Semantic_Type |
Pharmacologic Substance Organic Chemical |
| UMLS_CUI |
C2825026 |
| subClassOf |