loading...| Preferred Name |
Primary lateral sclerosis |
| ID |
http://www.orpha.net/ORDO/Orphanet_35689 |
| alternative_term |
PLS Adult-onset PLS Adult-onset primary lateral sclerosis |
| definition |
Primary lateral sclerosis (PLS) is an idiopathic non-familial motor neuron disease characterized by slowly progressive upper motor neuron dysfunction leading to spasticity, mild weakness in voluntary muscle movement, hyperreflexia, and loss of motor speech production. |
| definition_citation |
Orphanet |
| expertlink |
https://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=en&Expert=35689 |
| has_age_of_onset |
Adult Elderly |
| has_inheritance |
Autosomal recessive Not applicable Autosomal dominant |
| hasDbXref |
UMLS:C0154682 ICD-11:8B60.4 ICD-10:G12.2 MedDRA:10036704 OMIM:611637 |
| label |
Primary lateral sclerosis |
| notation |
ORPHA:35689 |
| part_of |
http://www.orpha.net/ORDO/Orphanet_183500 |
| prefixIRI |
ORDO:Orphanet_35689 |
| prefLabel |
Primary lateral sclerosis |
| present_in |
Europe AND has_point_prevalence_average_value : 1.5 AND has_point_prevalence_range : 1-9 / 100 000 |
| treeView |
http://www.orpha.net/ORDO/Orphanet_183500 |
| subClassOf |