-
anatomical entity - cellular response to toxic substance
- continuant
- occurrent
- processual entity
- receptor-type tyrosine-protein phosphatase C
- regulation of body fluid levels
- regulation of hormone levels
- regulation of neurotransmitter levels
- regulation of synapse structure or activity
- role
- role
- subatomic particle
| Preferred Name |
receptor-type tyrosine-protein phosphatase C |
| Synonyms |
leukocyte common antigen CD45 PTPRC L-CA lymphocyte antigen 5 T200 ly-5 |
| Definitions |
Category=gene. Requested by=CL. A protein that is a translation product of the human PTPRC gene or a 1:1 ortholog thereof. It is composed of an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic protein-tyrosine phosphatase domains. Contains 1 to 3 copies of the Fibronectin type III domain (Pfam:PF00041) followed by two copies of the Protein-tyrosine phosphatase (Pfam:PF00102) domain. Receptor-type tyrosine-protein phosphatase C (CD45) regulates signal transduction and lymphocyte activation by specific association with receptor molecules on T and B cells. Multiple isoforms of CD45 (180-235 kDa) can be generated asa result of alternative splicing of three variable exons 4(A), 5(B) and 6(C), encoding sequences at the N-terminal extracellular domain of the molecule. |
| ID |
http://purl.obolibrary.org/obo/PR_000001006 |
| comment |
Category=gene. Requested by=CL. |
| database_cross_reference |
PIRSF:PIRSF002004 IUPHARobj:1852 |
| definition |
A protein that is a translation product of the human PTPRC gene or a 1:1 ortholog thereof. It is composed of an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic protein-tyrosine phosphatase domains. Contains 1 to 3 copies of the Fibronectin type III domain (Pfam:PF00041) followed by two copies of the Protein-tyrosine phosphatase (Pfam:PF00102) domain. Receptor-type tyrosine-protein phosphatase C (CD45) regulates signal transduction and lymphocyte activation by specific association with receptor molecules on T and B cells. Multiple isoforms of CD45 (180-235 kDa) can be generated asa result of alternative splicing of three variable exons 4(A), 5(B) and 6(C), encoding sequences at the N-terminal extracellular domain of the molecule. |
| has_broad_synonym |
T200 |
| has_exact_synonym |
leukocyte common antigen PTPRC L-CA lymphocyte antigen 5 ly-5 |
| has_obo_namespace |
protein |
| has_related_synonym |
CD45 |
| id |
PR:000001006 |
| label |
receptor-type tyrosine-protein phosphatase C |
| notation |
PR:000001006 |
| prefLabel |
receptor-type tyrosine-protein phosphatase C |
| subClassOf |