loading...| Preferred Name |
hematopoietic stem cell |
| Synonyms |
hemopoietic stem cell HSC colony forming unit hematopoietic blood forming stem cell |
| Definitions |
Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative. A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119. |
| ID |
http://purl.obolibrary.org/obo/CL_0000037 |
| comment |
Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative. |
| capable of | |
| database_cross_reference |
CALOHA:TS-0448 BTO:0000725 VHOG:0001485 FMA:70337 MESH:D006412 FMA:86475 |
| definition |
A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119. |
| develops_from | |
| has_exact_synonym |
hemopoietic stem cell HSC blood forming stem cell |
| has_related_synonym |
colony forming unit hematopoietic |
| in_subset |
http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas |
| label |
hematopoietic stem cell |
| lacks_plasma_membrane_part |
http://purl.obolibrary.org/obo/PR_000001889 http://purl.obolibrary.org/obo/PR_000002981 http://purl.obolibrary.org/obo/PR_000001084 http://purl.obolibrary.org/obo/PR_000001012 http://purl.obolibrary.org/obo/PR_000001004 http://purl.obolibrary.org/obo/PR_000001289 http://purl.obolibrary.org/obo/PR_000001083 http://purl.obolibrary.org/obo/PR_000002978 http://purl.obolibrary.org/obo/PR_000001002 http://purl.obolibrary.org/obo/PR_000001020 |
| prefixIRI |
CL:0000037 |
| prefLabel |
hematopoietic stem cell |
| RO_0002175 | |
| treeView | |
| subClassOf |
http://purl.obolibrary.org/obo/CL_0000723 http://purl.obolibrary.org/obo/CL_0011026 |