Gene Ontology / 基因本体

Last uploaded: August 7, 2023
Preferred Name

neurofibrillary tangle

Synonyms

star-shaped neurofibrillary tangle

flame-shaped neurofibrillary tangle

Definitions

Neurofibrillary tangles have been found in aging population; their formation is increased in Alzheimer's disease patients (and in other neurological diseases) compared to normal controls (see PMID:848276 and PMID:8584267). Intracellular mass of paired, helically wound protein filaments (also called PHF) lying in the cytoplasm of neuronal cell bodies and neuritic cell processes. Neurofibrillary tangles contain an abnormally phosphorylated form of a microtubule-associated protein, tau. The shape of these inclusions may resemble a flame or a star.

ID

http://purl.obolibrary.org/obo/GO_0097418

comment

Neurofibrillary tangles have been found in aging population; their formation is increased in Alzheimer's disease patients (and in other neurological diseases) compared to normal controls (see PMID:848276 and PMID:8584267).

created_by

pr

creation_date

2012-11-06T16:49:35Z

database_cross_reference

NIF_Subcellular:nlx_subcell_20090201

NIF_Subcellular:sao2409833926

NIF_Subcellular:nlx_subcell_20090202

definition

Intracellular mass of paired, helically wound protein filaments (also called PHF) lying in the cytoplasm of neuronal cell bodies and neuritic cell processes. Neurofibrillary tangles contain an abnormally phosphorylated form of a microtubule-associated protein, tau. The shape of these inclusions may resemble a flame or a star.

has_narrow_synonym

star-shaped neurofibrillary tangle

flame-shaped neurofibrillary tangle

has_obo_namespace

cellular_component

id

GO:0097418

label

neurofibrillary tangle

notation

GO:0097418

prefLabel

neurofibrillary tangle

treeView

inclusion body

subClassOf

inclusion body

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Mapping To Ontology Source
neurofibrillary tangle BRENDA Tissue and Enzyme Source Ontology / 布兰达组织和酶源本体 LOOM
neurofibrillary tangle 中国人类表型本体 / Human Phenotype Ontology China LOOM
neurofibrillary tangle 中国人类表型本体 / Human Phenotype Ontology China SAME_URI