loading...| Preferred Name |
Amifostine |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C488 |
| Accepted_Therapeutic_Use_For |
Cisplatin-induced nephrotoxicity; Radiation-induced mucositis and xerostomia |
| CAS_Registry |
112901-68-5 |
| Chemical_Formula |
C5H15N2O3PS.3H2O |
| code |
C488 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177406 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
| Contributing_Source |
CTRP GDC FDA PCDC |
| DEFINITION |
The trihydrate form of a phosphorylated aminosulfhydryl compound. After dephosphorylation of amifostine by alkaline phosphatase to an active free sulfhydryl (thiol) metabolite, the thiol metabolite binds to and detoxifies cytotoxic platinum-containing metabolites of cisplatin and scavenges free radicals induced by cisplatin and ionizing radiation. The elevated activity of this agent in normal tissues results from both the relative abundance of alkaline phosphatase in normal tissues and the greater vascularity of normal tissues compared to tumor tissues. |
| Display_Name |
Amifostine |
| FDA_UNII_Code |
M487QF2F4V |
| FULL_SYN |
Gammaphos WR2721 Ethyol Aminopropylaminoethylthiophosphoric Acid Trihydrate Amifostine Trihydrate WR 2721 Amifostine Cytofos YM-08310 Ethiofos APAETP AMIFOSTINE S-2-(3-Aminopropylamino)ethylphosphorothioic Acid Trihydrate WR-2721 2-[(3-Aminopropyl)amino]ethanethiol Dihydrogen Phosphate Ester Trihydrate S-(N-(3-Aminopropyl)-2-aminoethyl)thiophosphoric Acid Trihydrate |
| Is_PCDC_GCT_Authorized_Value_For_Variable | |
| Is_Value_For_GDC_Property | |
| label |
Amifostine |
| Legacy Concept Name |
Amifostine |
| Maps_To |
Amifostine |
| NCI_Drug_Dictionary_ID |
39741 |
| NSC Number |
296961 |
| PDQ_Closed_Trial_Search_ID |
39741 |
| PDQ_Open_Trial_Search_ID |
39741 |
| Preferred_Name |
Amifostine |
| prefixIRI |
Thesaurus:C488 |
| prefLabel |
Amifostine |
| Semantic_Type |
Pharmacologic Substance Organic Chemical |
| UMLS_CUI |
C0015020 |
| subClassOf |