loading...| Preferred Name |
nucleotide excision repair pathway |
| Synonyms |
NER pathway nucleotide-excision repair Nucleotide Excision Repair |
| Definitions |
The nucleotide excision repair pathway is an important mechanism for the detection of helix-distorting base alterations. Unlike the base excision repair pathway that only removes the damaged bases, the NER pathway removes an entire lesion-containing segment. The single-strand gap thus introduced is filled in by DNA polymerase using the undamaged strand as a template. The pathway can be subdivided into two sub-pathways: transcription-coupled and global genome repair. They only differ in the lesion recognition step while the core repair component is shared. |
| ID |
http://purl.obolibrary.org/obo/PW_0000130 |
| definition |
The nucleotide excision repair pathway is an important mechanism for the detection of helix-distorting base alterations. Unlike the base excision repair pathway that only removes the damaged bases, the NER pathway removes an entire lesion-containing segment. The single-strand gap thus introduced is filled in by DNA polymerase using the undamaged strand as a template. The pathway can be subdivided into two sub-pathways: transcription-coupled and global genome repair. They only differ in the lesion recognition step while the core repair component is shared. |
| has_obo_namespace |
pathway |
| has_related_synonym |
NER pathway nucleotide-excision repair Nucleotide Excision Repair |
| id |
PW:0000130 |
| label |
nucleotide excision repair pathway |
| notation |
PW:0000130 |
| prefLabel |
nucleotide excision repair pathway |
| treeView | |
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C91447 | National Cancer Institute Thesaurus / 美国国家癌症研究所词典 | LOOM |