loading...| Preferred Name |
PF-06446846 |
| Synonyms |
PF-846 PF-06446846 PF06446846 N-(3-chloropyridin-2-yl)-N-[(3R)-piperidin-3-yl]-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)benzamide PF 06446846 |
| Definitions |
A triazolopyridine that is 3H-[1,2,3]triazolo[4,5-b]pyridine substituted by a 4-{(3-chloropyridin-2-yl)[(3R)-piperidin-3-yl]carbamoyl}phenyl group at position 3. It is a potent inhibitor of PCSK9. |
| ID |
http://purl.obolibrary.org/obo/CHEBI_189659 |
| charge |
0 |
| database_cross_reference |
PMID:29878763 Chemspider:74849329 PMID:31867167 PDBeChem:MVM PMID:34359627 CAS:1632250-49-7 PMID:28323820 Patent:US9227956 PMID:33801308 PMID:33009412 PMID:31160784 |
| definition |
A triazolopyridine that is 3H-[1,2,3]triazolo[4,5-b]pyridine substituted by a 4-{(3-chloropyridin-2-yl)[(3R)-piperidin-3-yl]carbamoyl}phenyl group at position 3. It is a potent inhibitor of PCSK9. |
| formula |
C22H20ClN7O |
| has role | |
| has_exact_synonym |
PF-06446846 N-(3-chloropyridin-2-yl)-N-[(3R)-piperidin-3-yl]-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)benzamide |
| has_obo_namespace |
chebi_ontology |
| has_related_synonym |
PF-846 PF06446846 PF 06446846 |
| id |
CHEBI:189659 |
| in_subset | |
| inchi |
InChI=1S/C22H20ClN7O/c23-18-5-2-12-25-20(18)29(17-4-1-11-24-14-17)22(31)15-7-9-16(10-8-15)30-21-19(27-28-30)6-3-13-26-21/h2-3,5-10,12-13,17,24H,1,4,11,14H2/t17-/m1/s1 |
| inchikey |
FDTXHWQFIXYHCL-QGZVFWFLSA-N |
| label |
PF-06446846 |
| mass |
433.900 |
| monoisotopicmass |
433.14179 |
| notation |
CHEBI:189659 |
| prefLabel |
PF-06446846 |
| smiles |
ClC1=CC=CN=C1N([C@@H]1CCCNC1)C(=O)C1=CC=C(C=C1)N1N=NC2=CC=CN=C12 |
| treeView |
http://purl.obolibrary.org/obo/CHEBI_26151 http://purl.obolibrary.org/obo/CHEBI_22702 http://purl.obolibrary.org/obo/CHEBI_140326 |
| subClassOf |
http://purl.obolibrary.org/obo/CHEBI_26151 http://purl.obolibrary.org/obo/CHEBI_22702 http://purl.obolibrary.org/obo/CHEBI_140326 |