loading...| Preferred Name |
G-protein coupled receptor |
| Synonyms |
fam:GPCR seven-transmembrane receptor 7TM receptor |
| Definitions |
Category=family. Classification based on GRAFS system. [PMID:12761335] A protein that has G protein-coupled receptor (GPCR) activity. Each GPCR consists of a single polypeptide with an extracellular N-terminus, an intracellular C-terminus and seven hydrophobic transmembrane domains (TM1-TM7) linked by three extracellular loops (ECL1-ECL3) and three intracellular loops (ICL1-ICL3). GPCRs function as part of a heterotrimeric complex to transmit an extracellular signal across the membrane by activating an associated G-protein via the exchange of GDP for GTP on the alpha subunit. |
| ID |
http://purl.obolibrary.org/obo/PR_000030035 |
| comment |
Category=family. Classification based on GRAFS system. [PMID:12761335] |
| database_cross_reference |
IUPHARfam:694 |
| has exact synonym |
fam:GPCR |
| has_broad_synonym |
seven-transmembrane receptor 7TM receptor |
| has_obo_namespace |
protein |
| id |
PR:000030035 |
| imported from | |
| label |
G-protein coupled receptor |
| notation |
PR:000030035 |
| prefLabel |
G-protein coupled receptor |
| textual definition |
A protein that has G protein-coupled receptor (GPCR) activity. Each GPCR consists of a single polypeptide with an extracellular N-terminus, an intracellular C-terminus and seven hydrophobic transmembrane domains (TM1-TM7) linked by three extracellular loops (ECL1-ECL3) and three intracellular loops (ICL1-ICL3). GPCRs function as part of a heterotrimeric complex to transmit an extracellular signal across the membrane by activating an associated G-protein via the exchange of GDP for GTP on the alpha subunit. |
| subClassOf |