loading...| Preferred Name |
Mycophenolic Acid |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C673 |
| Accepted_Therapeutic_Use_For |
Prophylaxis of organ rejection after allogenic renal; cardiac; or hepatic transplants; psoriasis |
| CAS_Registry |
24280-93-1 483-60-3 |
| CHEBI_ID |
CHEBI:168396 |
| Chemical_Formula |
C17H20O6 |
| code |
C673 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 |
| Contributing_Source |
CTRP GDC FDA |
| DEFINITION |
An antineoplastic antibiotic derived from various Penicillium fungal species. Mycophenolic acid is an active metabolite of the prodrug mycophenolate mofetil. Mycophenolic acid inhibits inosine monophosphate dehydrogenase (IMPDH), preventing the formation of guanosine monophosphate and synthesis of lymphocyte DNA that results in inhibition of lymphocyte proliferation, antibody production, cellular adhesion, and migration of T and B lymphocytes. Mycophenolic acid also has antibacterial, antifungal, and antiviral activities. (NCI04) |
| Display_Name |
Mycophenolic Acid |
| FDA_UNII_Code |
HU9DX48N0T |
| FULL_SYN |
Acidum mycophenolicum Lilly-68618 Acido micofenolico 4-Hexenoic acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-, (E)- MYCOPHENOLIC ACID Myfortic Acide mycophenolique 4-Hexenoic acid, 6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-, (E)- Mycophenolic Acid MPA Ly 68618 |
| Has_Salt_Form | |
| Is_Value_For_GDC_Property | |
| label |
Mycophenolic Acid |
| Legacy Concept Name |
Mycophenolic_Acid |
| Maps_To |
Mycophenolic Acid |
| NCI_Drug_Dictionary_ID |
732227 |
| NSC Number |
129185 |
| PDQ_Closed_Trial_Search_ID |
732227 |
| PDQ_Open_Trial_Search_ID |
732227 |
| Preferred_Name |
Mycophenolic Acid |
| prefixIRI |
Thesaurus:C673 |
| prefLabel |
Mycophenolic Acid |
| Semantic_Type |
Pharmacologic Substance Organic Chemical Antibiotic |
| UMLS_CUI |
C0026933 |
| subClassOf |