Medical Subject Headings / 医学主题词表

Last uploaded: September 7, 2023

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Preferred Name	Sirolimus
Synonyms	AY 22-989
Definitions	A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.
ID	http://purl.bioontology.org/ontology/MESH/D020123
altLabel	AY 22-989 I2190A I 2190A I-2190A Rapamune AY 22989 Rapamycin AY 22 989
AQL	AA AD AE AG AI AN BL CF CH CL CS EC HI IM IP ME PD PK PO RE SD ST TO TU UR
cui	C2350768 C0072980 C0878382 C0813828
DC	1
definition	A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.
DX	19990101
HN	99; use SIROLIMUS (NM) 1980-97
Inverse of AQ	http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000819 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000528 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000031 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000600 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000627
Inverse of RB	W36ZG6FT64 0
isa	http://purl.bioontology.org/ontology/MESH/D000900 http://purl.bioontology.org/ontology/MESH/D000903 http://purl.bioontology.org/ontology/MESH/D000935 http://purl.bioontology.org/ontology/MESH/D007166
LT	TRD
Machine permutation	99; RAPAMYCIN (now SIROLIMUS) was indexed under POLYENES 1976-98
Mapped from	http://purl.bioontology.org/ontology/MESH/C489443 http://purl.bioontology.org/ontology/MESH/C558961 http://purl.bioontology.org/ontology/MESH/C081453 http://purl.bioontology.org/ontology/MESH/C038313 http://purl.bioontology.org/ontology/MESH/C401859 http://purl.bioontology.org/ontology/MESH/C539629 http://purl.bioontology.org/ontology/MESH/C085325 http://purl.bioontology.org/ontology/MESH/C518022 http://purl.bioontology.org/ontology/MESH/C515074 http://purl.bioontology.org/ontology/MESH/C558962 http://purl.bioontology.org/ontology/MESH/C117998 http://purl.bioontology.org/ontology/MESH/C578609 http://purl.bioontology.org/ontology/MESH/C488301 http://purl.bioontology.org/ontology/MESH/C000634228 http://purl.bioontology.org/ontology/MESH/C476498 http://purl.bioontology.org/ontology/MESH/C558963 http://purl.bioontology.org/ontology/MESH/C514512 http://purl.bioontology.org/ontology/MESH/C492085
MDA	19980611
MMR	20160701
MN	D02.540.505.760
notation	D020123
PA	D000935 D000903 D007166 D000900
prefLabel	Sirolimus
RR	53123-88-9 (Sirolimus)
TERMUI	T059904 T707737 T059903 T059901 T059902
TH	FDA SRS (2014) US DE USAN (19XX) NLM (2009) BAN (19XX) CA FR NLM (1999) INN (19XX) UK ES
tui	T109 T195 T121
subClassOf	http://purl.bioontology.org/ontology/MESH/D018942

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/DRON_00013476	Coronavirus Infectious Disease Ontology / 冠状病毒感染性疾病本体	LOOM
http://purl.bioontology.org/ontology/ATC/S01XA23	Anatomical Therapeutic Chemical Classification / 解剖学治疗学及化学分类系统	CUI
http://purl.bioontology.org/ontology/ATC/S01XA23	Anatomical Therapeutic Chemical Classification / 解剖学治疗学及化学分类系统	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU013897	Logical Observation Identifier Names and Codes / 逻辑观察标识符名称和代码	CUI
http://purl.bioontology.org/ontology/LNC/MTHU013897	Logical Observation Identifier Names and Codes / 逻辑观察标识符名称和代码	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1212	National Cancer Institute Thesaurus / 美国国家癌症研究所词典	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148624	Ontology of Drug Adverse Events / 药物不良反应本体	LOOM
http://purl.bioontology.org/ontology/LNC/LA31622-6	Logical Observation Identifier Names and Codes / 逻辑观察标识符名称和代码	CUI
http://purl.bioontology.org/ontology/LNC/LA31622-6	Logical Observation Identifier Names and Codes / 逻辑观察标识符名称和代码	LOOM
http://purl.bioontology.org/ontology/ATC/L04AA10	Anatomical Therapeutic Chemical Classification / 解剖学治疗学及化学分类系统	CUI
http://purl.bioontology.org/ontology/ATC/L04AA10	Anatomical Therapeutic Chemical Classification / 解剖学治疗学及化学分类系统	LOOM
http://purl.bioontology.org/ontology/LNC/LP21368-3	Logical Observation Identifier Names and Codes / 逻辑观察标识符名称和代码	CUI
http://purl.bioontology.org/ontology/LNC/LP21368-3	Logical Observation Identifier Names and Codes / 逻辑观察标识符名称和代码	LOOM
http://purl.obolibrary.org/obo/CHEBI_9168	Chemical Entities of Biological Interest Ontology / 生物相关的化学实体本体	LOOM
http://purl.obolibrary.org/obo/CHEBI_9168	The Drug Ontology / 药物本体	LOOM
http://purl.obolibrary.org/obo/CHEBI_9168	Coronavirus Infectious Disease Ontology / 冠状病毒感染性疾病本体	LOOM
http://purl.obolibrary.org/obo/CHEBI_9168	Experimental Factor Ontology / 实验性因素本体	LOOM