loading...| Preferred Name |
Carbon C 11-JNJ-63779586 |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C148497 |
| code |
C148497 |
| Concept_In_Subset | |
| DEFINITION |
A radioconjugate composed of JNJ-63779586 labeled with the positron-emitting isotope carbon C 11, with potential use in imaging via positron emission tomography (PET). Upon administration of carbon C 11-JNJ-63779586, the JNJ-63779586 moiety acts as a substrate for the efflux transporter P-glycoprotein (P-gp) and the breast cancer resistance protein (BCRP). Upon PET imaging, this radioligand may allow for the assessment of P-gp and BCRP function and expression in tumors. As P-gp and BCRP activity may influence response to therapy, measuring P-gp and BCRP activity may be beneficial when choosing chemotherapy. P-gp and BCRP, efflux transporters, are overexpressed by certain tumor cells and may contribute to multidrug resistance to chemotherapy. |
| FULL_SYN |
Carbon C 11-JNJ-63779586 11C-JNJ-63779586 |
| label |
Carbon C 11-JNJ-63779586 |
| NCI_Drug_Dictionary_ID |
792629 |
| NCI_META_CUI |
CL551045 |
| PDQ_Closed_Trial_Search_ID |
792629 |
| PDQ_Open_Trial_Search_ID |
792629 |
| Preferred_Name |
Carbon C 11-JNJ-63779586 |
| prefixIRI |
Thesaurus:C148497 |
| prefLabel |
Carbon C 11-JNJ-63779586 |
| Semantic_Type |
Indicator, Reagent, or Diagnostic Aid |
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| There are currently no mappings for this class. | |||