loading...| Preferred Name |
Ketoconazole |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C605 |
| Accepted_Therapeutic_Use_For |
Seborrheic Dermatitis; Prostate cancer |
| ALT_DEFINITION |
A drug that treats infection caused by a fungus. It is also used as a treatment for prostate cancer because it can block the production of male sex hormones. |
| CAS_Registry |
65277-42-1 |
| CHEBI_ID |
CHEBI:47519 |
| Chemical_Formula |
C26H28Cl2N4O4 |
| code |
C605 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
| Contributing_Source |
OORO CTRP GDC FDA |
| DEFINITION |
A synthetic derivative of phenylpiperazine with broad antifungal properties and potential antineoplastic activity. Ketoconazole inhibits sterol 14-a-dimethylase, a microsomal cytochrome P450-dependent enzyme, thereby disrupting synthesis of ergosterol, an important component of the fungal cell wall. (NCI04) |
| Display_Name |
Ketoconazole |
| FDA_UNII_Code |
R9400W927I |
| FULL_SYN |
Panfungol Fungoral Ketoderm Xolegel ketoconazole Ketoconazole Nizoral Fungarest KETOCONAZOLE Ketoisdin Cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazole-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine R-41400 Orifungal M |
| Is_Value_For_GDC_Property | |
| label |
Ketoconazole |
| Legacy Concept Name |
Ketoconazole |
| Maps_To |
Ketoconazole |
| NCI_Drug_Dictionary_ID |
39488 |
| NSC Number |
317629 |
| PDQ_Closed_Trial_Search_ID |
39488 |
| PDQ_Open_Trial_Search_ID |
39488 |
| Preferred_Name |
Ketoconazole |
| prefixIRI |
Thesaurus:C605 |
| prefLabel |
Ketoconazole |
| Semantic_Type |
Pharmacologic Substance Organic Chemical |
| UMLS_CUI |
C0022625 |
| subClassOf |