loading...| Preferred Name |
Integrin Alpha-M |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17373 |
| code |
C17373 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 |
| Contributing_Source |
CTRP |
| DEFINITION |
Integrin alpha-M (1152 aa, ~127 kDa) is encoded by the human ITGAM gene. This protein is involved in both leukocyte adhesion and the phagocytosis of complement coated particles. |
| DesignNote |
An adhesion-promoting leukocyte surface integrin heterodimer contains an alpha subunit of CD11b antigen and a beta subunit of CD18 antigen. The heterodimer functions as a receptor for complement 3, and in cell-cell and cell-substrate adhesive interactions. Major surface antigens on leukocytes include CR3A, LFA-1, and p150,95, which share a common beta chain linked to one of three alpha distinctive chains. They promote adhesion of granulocytes to each other and to endothelial cells. The CR3A alpha subunit (CD11b) is homologous to the alpha subunit of IIb/IIIa, a platelet glycoprotein that also serves adhesive functions. CD11b also exhibits significant homology with portions of the alpha subunits of fibronectin, vitronectin, platelet IIb/IIIa receptors, and p150,95. The protein consists of an N-terminal extracytoplasmic domain, a transmembrane segment, and a short C-terminal cytoplasmic domain. |
| Display_Name |
Integrin Alpha-M |
| FULL_SYN |
CD11 Antigen-Like Family Member B CD11b Neutrophil Adherence Receptor MAC1 Alpha CR-3 Alpha Chain Leukocyte Adhesion Receptor MO1 Integrin Alpha M MO1 Alpha Neutrophil Adherence Receptor Alpha-M Subunit ITGAM Cell Surface Glycoprotein MAC-1 Subunit Alpha Macrophage Antigen Alpha Polypeptide CD11b Antigen Integrin Alpha-M Complement Receptor Type 3, Alpha Subunit |
| label |
Integrin Alpha-M |
| Legacy Concept Name |
Integrin_Alpha-M |
| OMIM_Number |
120980 |
| Preferred_Name |
Integrin Alpha-M |
| prefixIRI |
Thesaurus:C17373 |
| prefLabel |
Integrin Alpha-M |
| Semantic_Type |
Amino Acid, Peptide, or Protein |
| Swiss_Prot |
P11215 |
| UMLS_CUI |
C1701032 |
| subClassOf |