loading...| Preferred Name |
Langerhans Cell Histiocytosis |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C3107 |
| ALT_DEFINITION |
A group of rare disorders in which too many Langerhans cells (a type of white blood cell) grow in certain tissues and organs including the bones, skin, and lungs, and damage them. Langerhans cell histiocytosis may also affect the pituitary gland (which makes hormones that control other glands and many body functions, especially growth). Langerhans cell histiocytosis is most common in children and young adults. Tissue infiltration by Langerhans cells (histiocytes). When infiltration involves the pituitary stalk or gland, presentation includes diabetes insipidus, which is sometimes accompanied by other pituitary dysfunction. |
| code |
C3107 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C126659 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C168661 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C168655 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C168657 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C103078 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118168 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192842 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C165258 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C90259 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102905 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118467 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C168662 |
| Contributing_Source |
NICHD CTEP CTRP GDC Cellosaurus |
| DEFINITION |
A neoplastic proliferation of Langerhans cells which contain Birbeck granules by ultrastructural examination. Three major overlapping syndromes are recognized: eosinophilic granuloma, Letterer-Siwe disease, and Hand-Schuller-Christian disease. The clinical course is generally related to the number of organs affected at presentation. (WHO, 2001) |
| Display_Name |
Langerhans Cell Histiocytosis |
| FULL_SYN |
Langerhans Cell Granulomatosis Langerhans Cell Histiocytosis Langerhans cell histiocytosis Histiocytosis X Langerhans cell histiocytosis, NOS Langerhans cell granulomatosis LCH |
| ICD-O-3_Code |
9751/1 9751/3 9753/1 9754/3 9752/1 |
| Is_Value_For_GDC_Property | |
| label |
Langerhans Cell Histiocytosis |
| Legacy Concept Name |
Langerhans_Cell_Histiocytosis |
| Maps_To |
9751/1 9751/3 Langerhans cell histiocytosis, NOS Langerhans cell granulomatosis Histiocytosis X, NOS |
| Neoplastic_Status |
Undetermined |
| Preferred_Name |
Langerhans Cell Histiocytosis |
| prefixIRI |
Thesaurus:C3107 |
| prefLabel |
Langerhans Cell Histiocytosis |
| Semantic_Type |
Neoplastic Process |
| UMLS_CUI |
C0019621 |
| subClassOf |