loading...| Preferred Name |
Interleukin-5 Receptor Subunit Alpha |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26269 |
| code |
C26269 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 |
| Contributing_Source |
CTRP |
| DEFINITION |
Interleukin-5 receptor subunit alpha (420 aa, ~48 kDa) is encoded by the human IL5RA gene. This protein is involved in the modulation of interleukin-5 signaling. |
| DesignNote |
This protein is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. (from LocusLink) |
| Display_Name |
Interleukin-5 Receptor Subunit Alpha |
| FULL_SYN |
CD125 IL-5RA Interleukin 5 Receptor Type 3 Interleukin 5 Receptor Alpha Interleukin-5 Receptor Alpha Chain IL-5 Receptor Subunit Alpha IL-5R Subunit Alpha Interleukin-5 Receptor Subunit Alpha CD125 Antigen Interleukin 5 Receptor, Alpha Interleukin 5 Receptor CDw125 Interleukin 5 Receptor Alpha Subunit IL5RA IL-5R-Alpha |
| label |
Interleukin-5 Receptor Subunit Alpha |
| Legacy Concept Name |
Interleukin-5_Receptor_Alpha |
| OMIM_Number |
147851 |
| Preferred_Name |
Interleukin-5 Receptor Subunit Alpha |
| prefixIRI |
Thesaurus:C26269 |
| prefLabel |
Interleukin-5 Receptor Subunit Alpha |
| Semantic_Type |
Receptor Amino Acid, Peptide, or Protein |
| Swiss_Prot |
Q01344 |
| UMLS_CUI |
C1704269 |
| subClassOf |