loading...| Preferred Name |
Diethylstilbestrol |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C433 |
| Accepted_Therapeutic_Use_For |
Breast cancer; Prostate cancer |
| ALT_DEFINITION |
A synthetic form of the hormone estrogen that was prescribed to pregnant women between about 1940 and 1971 because it was thought to prevent miscarriages. Diethylstilbestrol may increase the risk of uterine, ovarian, or breast cancer in women who took it. It also has been linked to an increased risk of clear cell carcinoma of the vagina or cervix in daughters exposed to diethylstilbestrol before birth. |
| CAS_Registry |
56-53-1 |
| CHEBI_ID |
CHEBI:41922 |
| Chemical_Formula |
C18H20O2 |
| code |
C433 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923 |
| Contributing_Source |
OORO FDA |
| DEFINITION |
A synthetic, nonsteroidal form of estrogen. A well-known teratogen and carcinogen, diethylstilbestrol inhibits the hypothalamic-pituitary-gonadal axis, thereby blocking the testicular synthesis of testosterone, lowering plasma testosterone, and inducing a chemical castration. |
| FDA_UNII_Code |
731DCA35BT |
| FULL_SYN |
Estrobene 4,4'-Dihydroxy-.alpha., .beta.-diethylstilbene Oestrogenine Estromenin Stilkap 3-Hexene,3,4-bis(p-hydroxyphenyl)- Diethylstilbenediol Estrosyn 3,4-Bis(p-hydroxyphenyl)-3-hexene Milestrol Oestromon Alpha,alpha'-diethylstilbenediol 4,4'-Dihydroxy-alpha,beta-diethylstilbene Stilboefral Vagestrol Palestrol (E)-4,4'-(1,2-diethyl-1,2-ethenediyl)bisphenol Domestrol Diethylstilbestrol Oestromensyl diethylstilbestrol Microest Grafestrol Diethylstilboestrol Sibol Trans-bis-(hydroxy-4-phenyl)-3,4 hexene-3 Diastyl Boestrol Synestrin Acnestrol Fonatol 3, 4-Bis(p-hydroxyphenyl)-3-hexene Stilbetin Apstil Distilbene diethylstilbestrol (DES) Neo-Oestronol I DES Stilboestrol Bufon Antigestil Stilboestroform Serral Diethylstilbestrolum Oestromenin Stilbestrol Makarol DIETHYLSTILBESTROL Synthoestrin Cyren A Sexocretin .alpha., .alpha.'-Diethylstilbenediol |
| label |
Diethylstilbestrol |
| Legacy Concept Name |
Diethylstilbestrol |
| NCI_Drug_Dictionary_ID |
43081 |
| NSC Number |
3070 |
| PDQ_Closed_Trial_Search_ID |
43081 |
| PDQ_Open_Trial_Search_ID |
43081 |
| Preferred_Name |
Diethylstilbestrol |
| prefixIRI |
Thesaurus:C433 |
| prefLabel |
Diethylstilbestrol |
| Semantic_Type |
Pharmacologic Substance Organic Chemical |
| UMLS_CUI |
C0012203 |
| subClassOf |