loading...| Preferred Name |
pro-B cell |
| Synonyms |
progenitor B-cell pro-B-cell pro-B lymphocyte progenitor B lymphocyte pre-B cell (Philadelphia nomenclature) pre-pro B cell pro-B-lymphocyte progenitor B-lymphocyte progenitor B cell |
| Definitions |
A progenitor cell of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but not yet fully committed to the B cell lineage until the expression of PAX5 occurs. Human pro-B cells are reportedly CD10-positive, CD22-positive, CD34-positive, CD38-positive, CD45-low, CD48-positive, CD79a-positive, CD127-positive, CD184-positive, RAG-positive, TdT-positive, Vpre-B-positive, pre-BCR-negative, IgD-negative, and IgM-negative. Transcription factors expressed: Pax5-positive, EBF-positive, E2A-negative, Ikaros-negative, and PU.1-negative. |
| ID |
http://purl.obolibrary.org/obo/CL_0000826 |
| comment |
Human pro-B cells are reportedly CD10-positive, CD22-positive, CD34-positive, CD38-positive, CD45-low, CD48-positive, CD79a-positive, CD127-positive, CD184-positive, RAG-positive, TdT-positive, Vpre-B-positive, pre-BCR-negative, IgD-negative, and IgM-negative. Transcription factors expressed: Pax5-positive, EBF-positive, E2A-negative, Ikaros-negative, and PU.1-negative. |
| database_cross_reference |
BTO:0003104 |
| definition |
A progenitor cell of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but not yet fully committed to the B cell lineage until the expression of PAX5 occurs. |
| has_broad_synonym |
pre-pro B cell |
| has_exact_synonym |
progenitor B-cell pro-B-cell pro-B lymphocyte progenitor B lymphocyte pro-B-lymphocyte progenitor B-lymphocyte progenitor B cell |
| has_related_synonym |
pre-B cell (Philadelphia nomenclature) |
| in_subset |
http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas |
| label |
pro-B cell |
| prefixIRI |
obo2:CL_0000826 |
| prefLabel |
pro-B cell |
| RO_0002175 | |
| subClassOf |