loading...| Preferred Name |
Spironolactone |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C840 |
| CAS_Registry |
52-01-7 |
| CHEBI_ID |
CHEBI:9241 |
| Chemical_Formula |
C24H32O4S |
| code |
C840 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 |
| Contributing_Source |
CTRP FDA |
| DEFINITION |
A synthetic 17-spironolactone corticosteroid with potassium-sparing diuretic, antihypertensive, and antiandrogen activities.Spironolactone competitively inhibits adrenocortical hormone aldosterone activity in the distal renal tubules, myocardium, and vasculature. This agent may inhibit the pathophysiologic effects of aldosterone produced in excess by various types of malignant and benign tumors. |
| Display_Name |
Spironolactone |
| FDA_UNII_Code |
27O7W4T232 |
| FULL_SYN |
Aldactone 17-Hydroxy-7alpha-mercapto-3-oxo-17alpha-pregn-4-ene-21-carboxylic Acid, gamma Lactone, Acetate SC 9420 Spironolactone SPIRONOLACTONE SPL |
| label |
Spironolactone |
| Legacy Concept Name |
Spironolactone |
| NCI_Drug_Dictionary_ID |
39444 |
| NSC Number |
150399 |
| PDQ_Closed_Trial_Search_ID |
39444 |
| PDQ_Open_Trial_Search_ID |
39444 |
| Preferred_Name |
Spironolactone |
| prefixIRI |
Thesaurus:C840 |
| prefLabel |
Spironolactone |
| Semantic_Type |
Pharmacologic Substance Organic Chemical |
| UMLS_CUI |
C0037982 |
| subClassOf |