loading...| Preferred Name |
Tocilizumab |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C84217 |
| Accepted_Therapeutic_Use_For |
Treatment of COVID-19-emergency use authorization (EUA). |
| CAS_Registry |
375823-41-9 |
| CHEBI_ID |
CHEBI:64360 |
| code |
C84217 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191404 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191670 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191387 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191200 |
| Contributing_Source |
ACC/AHA CTRP GDC FDA |
| DEFINITION |
A recombinant, humanized IgG1 monoclonal antibody directed against the interleukin-6 receptor (IL-6R) with immunosuppressant activity. Tocilizumab targets and binds to both the soluble form of IL-6R (sIL-6R) and the membrane-bound form (mIL-6R), thereby blocking the binding of IL-6 to its receptor. This prevents IL-6-mediated signaling. IL-6, a pro-inflammatory cytokine that plays an important role in the regulation of the immune response, is overproduced in autoimmune disorders, certain types of cancers and possibly various other inflammatory conditions. |
| Display_Name |
Tocilizumab |
| FDA_UNII_Code |
I031V2H011 |
| FULL_SYN |
RoActemra MRA Actemra TOCILIZUMAB Immunoglobulin G1, Anti-(Human Interleukin 6 Receptor) (Human-Mouse Monoclonal MRA Heavy Chain), Disulfide with Human-Mouse Monoclonal MRA Kappa-Chain, Dimer Tocilizumab IL-6 receptor monoclonal antibodies: tocilizumab R-1569 |
| Has_ACC-AHA_SARS2_Authorized_Value |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17998 |
| Has_Target | |
| Is_Value_For_GDC_Property | |
| label |
Tocilizumab |
| Maps_To |
Tocilizumab |
| NCI_Drug_Dictionary_ID |
713832 |
| PDQ_Closed_Trial_Search_ID |
713832 |
| PDQ_Open_Trial_Search_ID |
713832 |
| Preferred_Name |
Tocilizumab |
| prefixIRI |
Thesaurus:C84217 |
| prefLabel |
Tocilizumab |
| Semantic_Type |
Pharmacologic Substance |
| UMLS_CUI |
C1609165 |
| subClassOf |