loading...| Preferred Name |
osteoclast |
| Synonyms |
chondroclast |
| Definitions |
A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive. Morphology: Highly vesicular; markers: Surface: RANK, cFMS (MCSF receptor); Secreted: cathepsin K and TRAP (tartate resistant acid phosphatase); transcription factors: PU.1, cFOS, MITF, NFkB (p52); role or process: tissue remodelling: bone resorption; lineage: hematopoietic, myeloid. |
| ID |
http://purl.obolibrary.org/obo/CL_0000092 |
| comment |
Morphology: Highly vesicular; markers: Surface: RANK, cFMS (MCSF receptor); Secreted: cathepsin K and TRAP (tartate resistant acid phosphatase); transcription factors: PU.1, cFOS, MITF, NFkB (p52); role or process: tissue remodelling: bone resorption; lineage: hematopoietic, myeloid. |
| capable of | |
| database_cross_reference |
BTO:0000968 MESH:D010010 FMA:66781 CALOHA:TS-0721 |
| definition |
A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive. |
| develops_from | |
| has part |
http://purl.obolibrary.org/obo/PR_000001937 http://purl.obolibrary.org/obo/PR_000001944 http://purl.obolibrary.org/obo/PR_000007597 |
| has plasma membrane part | |
| has related synonym |
chondroclast |
| label |
osteoclast |
| part_of | |
| prefixIRI |
CL:0000092 |
| prefLabel |
osteoclast |
| treeView | |
| subClassOf |
http://purl.obolibrary.org/obo/CL_0001035 http://purl.obolibrary.org/obo/PR_000050567 |