loading...| Preferred Name |
lobe of prostate |
| Synonyms |
prostatic lobe prostate gland lobe lobe of prostate gland |
| Definitions |
A portion of a prostate that forms a lobe. |
| ID |
http://purl.obolibrary.org/obo/UBERON_0001328 |
| contributor | |
| database_cross_reference |
FMA:19570 SCTID:279692004 EMAPA:35712 MA:0001738 BTO:0000548 NCIT:C52726 UMLS:C0227970 |
| definition |
A portion of a prostate that forms a lobe. |
| has exact synonym |
prostatic lobe prostate gland lobe lobe of prostate gland |
| has_obo_namespace |
uberon |
| id |
UBERON:0001328 |
| label |
lobe of prostate |
| notation |
UBERON:0001328 |
| part_of | |
| prefLabel |
lobe of prostate |
| taxon_notes |
Anatomically, the human prostate gland is located between the base of the bladder and the rectum, and it completely surrounds the proximal urethra (Fig. 1A). It is a single alobular structure with central (CZ), peripheral (PZ) and transitional (TZ) zones. In contrast, the mouse prostate is not merged into one compact anatomical structure. It comprises four paired lobes situated circumferentially around the urethra, immediately caudal to the urinary bladder-namely, anterior (AP), dorsal (DP), lateral (LP), and ventral (VP) prostate (Fig. 1B). Often, the dorsal and the lateral lobes are thought of in combination and referred to as the dorsolateral (DLP) lobe as they share a ductal system. The mouse AP is considered analogous to the human CZ, which is rarely a site of neoplastic transformation in humans. The mouse DLP is considered most similar to the human PZ, which is the zone in which most carcinomas arise (Xue et al. 1997). These analogies, however, are limited as they are based solely on descriptive data and need to be re-evaluated using molecular techniques before the relationship between specific mouse prostate lobes and the human prostate zones is definitively asserted (Abate-Shen & Shen 2000). The mouse VP does not have a human homologue, and the human TZ does not have a murine homologue |
| treeView | |
| subClassOf |
http://purl.obolibrary.org/obo/UBERON_0000077 |