loading...| Preferred Name |
Clozapine |
| Synonyms |
5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)- |
| Definitions |
A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent. |
| ID |
http://purl.bioontology.org/ontology/MESH/D003024 |
| altLabel |
5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)- Leponex Clozaril |
| AQL |
AA AD AE AG AI AN BL CF CH CL CS EC HI IM IP ME PD PK PO RE SD ST TO TU UR |
| cui |
C0719386 C0009079 C0733560 |
| DC |
1 |
| definition |
A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent. |
| DX |
19910101 |
| HN |
91(75); was see under DIBENZAZEPINES 1975-90 |
| Inverse of AQ |
http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000819 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000528 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000031 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000600 http://purl.bioontology.org/ontology/MESH/Q000378 |
| Inverse of RB |
J60AR2IKIC 0 |
| isa |
http://purl.bioontology.org/ontology/MESH/D012702 |
| LT |
TRD |
| Machine permutation |
91; was see under DIBENZAZEPINES 1975-90 |
| Mapped from |
http://purl.bioontology.org/ontology/MESH/C094038 http://purl.bioontology.org/ontology/MESH/C061855 http://purl.bioontology.org/ontology/MESH/C108260 http://purl.bioontology.org/ontology/MESH/C061853 http://purl.bioontology.org/ontology/MESH/C079149 http://purl.bioontology.org/ontology/MESH/C411706 http://purl.bioontology.org/ontology/MESH/C000726499 http://purl.bioontology.org/ontology/MESH/C045393 http://purl.bioontology.org/ontology/MESH/C086632 http://purl.bioontology.org/ontology/MESH/C061854 http://purl.bioontology.org/ontology/MESH/C586625 http://purl.bioontology.org/ontology/MESH/C058272 http://purl.bioontology.org/ontology/MESH/C522904 http://purl.bioontology.org/ontology/MESH/C093454 |
| MDA |
19741119 |
| MMR |
20160528 |
| MN |
D03.633.300.240.220 |
| notation |
D003024 |
| PA |
D014150 D012702 D018756 |
| prefLabel |
Clozapine |
| RR |
5786-21-0 (Clozapine) |
| TERMUI |
T008784 T008783 T008785 |
| TH |
FDA SRS (2014) USP (19XX) UNK (19XX) NLM (1992) BAN (19XX) USAN (1969) INN (19XX) |
| tui |
T109 T121 |
| subClassOf |