loading...| Preferred Name |
Cyclin-Dependent Kinase 2 |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25842 |
| code |
C25842 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 |
| Contributing_Source |
CTRP |
| DEFINITION |
Cyclin-dependent kinase 2 (298 aa, ~34 kDa) is encoded by the human CDK2 gene. This protein is involved in the regulation of both phosphorylation of cyclins and the cell cycle progression from the G2 phase to mitosis. |
| DesignNote |
This protein kinase is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. It is involved in promoting DNA synthesis and cell cycle progression. This protein associates with and is regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene exist. Its N-terminal domain interacts with cyclins and C-terminal domain interacts with CSK1. (LocusLink, OMIM) |
| Display_Name |
Cyclin-Dependent Kinase 2 |
| FULL_SYN |
p33(CDK2) Cell Division Kinase 2 p33 Protein Kinase EC 2.7.11.22 CDC2-Related Protein Kinase Cyclin-Dependent Kinase 2 EC 2.7.1.11 CDK2 Cell Division Protein Kinase 2 |
| label |
Cyclin-Dependent Kinase 2 |
| Legacy Concept Name |
Cyclin-Dependent_Kinase-2 |
| OMIM_Number |
116953 |
| Preferred_Name |
Cyclin-Dependent Kinase 2 |
| prefixIRI |
Thesaurus:C25842 |
| prefLabel |
Cyclin-Dependent Kinase 2 |
| Semantic_Type |
Enzyme Amino Acid, Peptide, or Protein |
| Swiss_Prot |
P24941 |
| UMLS_CUI |
C0108855 |
| subClassOf |