loading...| Preferred Name |
Macrocephaly |
| Synonyms |
Big head Increased size of head Big calvaria Megacephaly Big skull Increased size of cranium Macrocrania Macrocephalus Large cranium Large head Large calvaria Large head circumference Increased size of skull Large skull Big cranium |
| Definitions |
Occipitofrontal (head) circumference greater than 97th centile compared to appropriate, age matched, sex-matched normal standards. Alternatively, a apparently increased size of the cranium. Macrocephaly can be due to hydrocephalus (increased CFSF), megalencephaly (increased brain volume) or thickening of the skull. Head circumference is measured from just above the glabella (the most prominent point on the frontal bone above the root of the nose) to the most posterior prominent point of the occipital bone using a tape measure. Some standard charts are organized by centiles [Hall et al. [2007]], others by standard deviations [Farkas, [1981]]. It is important to add an indication of how far above the normal standard the head circumference is if an accurate assessment of this can be made. Macrocephaly is an absolute term. The term relative macrocephaly can be used when the head size centile exceeds the centile for height, for example, head size at the 75th centile with height at the 5th centile for age and sex. |
| ID |
http://purl.obolibrary.org/obo/HP_0000256 |
| comment |
Macrocephaly can be due to hydrocephalus (increased CFSF), megalencephaly (increased brain volume) or thickening of the skull. Head circumference is measured from just above the glabella (the most prominent point on the frontal bone above the root of the nose) to the most posterior prominent point of the occipital bone using a tape measure. Some standard charts are organized by centiles [Hall et al. [2007]], others by standard deviations [Farkas, [1981]]. It is important to add an indication of how far above the normal standard the head circumference is if an accurate assessment of this can be made. Macrocephaly is an absolute term. The term relative macrocephaly can be used when the head size centile exceeds the centile for height, for example, head size at the 75th centile with height at the 5th centile for age and sex. |
| database_cross_reference |
UMLS:C4083076 UMLS:C4280663 UMLS:C4280664 UMLS:C4255213 Fyler:4335 |
| definition |
Occipitofrontal (head) circumference greater than 97th centile compared to appropriate, age matched, sex-matched normal standards. Alternatively, a apparently increased size of the cranium. |
| has_alternative_id |
HP:0005496 HP:0200135 HP:0005491 |
| has_broad_synonym |
Big head Increased size of head Big calvaria Big skull Large cranium Large calvaria Large skull Big cranium |
| has_exact_synonym |
Megacephaly Increased size of cranium Macrocrania Macrocephalus Large head Large head circumference Increased size of skull |
| has_obo_namespace |
human_phenotype |
| id |
HP:0000256 |
| in_subset | |
| label |
Macrocephaly |
| notation |
HP:0000256 |
| prefLabel |
Macrocephaly |
| treeView | |
| subClassOf |