loading...| Preferred Name |
Retinoblastoma |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C7541 |
| ALT_DEFINITION |
Cancer that forms in the tissues of the retina (the light-sensitive layers of nerve tissue at the back of the eye). Retinoblastoma usually occurs in children younger than 5 years. It may be hereditary or nonhereditary (sporadic). A malignant tumor that originates in the nuclear layer of the retina. As the most common primary tumor of the eye in children, retinoblastoma is still relatively uncommon, accounting for only 1% of all malignant tumors in pediatric patients. Approximately 95% of cases are diagnosed before age 5. These tumors may be multifocal, bilateral, congenital, inherited, or acquired. Seventy-five percent of retinoblastomas are unilateral; 60% occur sporadically. A predisposition to retinoblastoma has been associated with 13q14 cytogenetic abnormalities. Patients with the inherited form also appear to be at increased risk for secondary nonocular malignancies such as osteosarcoma, malignant fibrous histiocytoma, and fibrosarcoma. A malignant neoplasm originating in the nuclear layer of the retina. |
| code |
C7541 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C126659 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C168661 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C158520 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C168655 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C138188 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C103061 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C168657 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C88025 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C156966 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61410 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118168 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C189762 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C138190 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118464 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192842 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C179478 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C165258 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C90259 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C179491 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C156952 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102905 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C168662 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C99147 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132009 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C168656 |
| Contributing_Source |
MedDRA CPTAC NICHD CDISC CTEP CTRP GDC Cellosaurus PCDC |
| DEFINITION |
A malignant tumor that originates in the nuclear layer of the retina. As the most common primary tumor of the eye in children, retinoblastoma is still relatively uncommon, accounting for only 1% of all malignant tumors in pediatric patients. Approximately 95% of cases are diagnosed before age 5. These tumors may be multifocal, bilateral, congenital, inherited, or acquired. Seventy-five percent of retinoblastomas are unilateral; 60% occur sporadically. A predisposition to retinoblastoma has been associated with 13q14 cytogenetic abnormalities. Patients with the inherited form also appear to be at increased risk for secondary nonocular malignancies such as osteosarcoma, malignant fibrous histiocytoma, and fibrosarcoma. |
| Display_Name |
Retinoblastoma |
| FULL_SYN |
RETINOBLASTOMA, MALIGNANT Retinoblastoma, NOS RB retinoblastoma Retinoblastoma |
| ICD-O-3_Code |
9510/3 |
| Is_Value_For_GDC_Property | |
| label |
Retinoblastoma |
| Legacy Concept Name |
Retinoblastoma |
| Maps_To |
9510/3 Retinoblastoma, NOS Retinoblastoma |
| Neoplasm_Has_Special_Category | |
| Neoplastic_Status |
Malignant |
| Preferred_Name |
Retinoblastoma |
| prefixIRI |
Thesaurus:C7541 |
| prefLabel |
Retinoblastoma |
| Semantic_Type |
Neoplastic Process |
| UMLS_CUI |
C0035335 |
| subClassOf |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C3216 |