loading...| Preferred Name |
Anti-PD-1/LAG-3 Bispecific Antibody EMB-02 |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C179258 |
| code |
C179258 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 |
| Contributing_Source |
GDC |
| DEFINITION |
A bispecific antibody directed against the human negative immunoregulatory checkpoint receptors programmed cell death protein 1 (PD-1; PD1; PDCD1; CD279; Programmed Death 1) and lymphocyte activation gene 3 protein (LAG-3; LAG3; CD223), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, anti-PD-1/LAG-3 bispecific antibody EMB-02 targets and binds to both PD-1 and LAG-3 expressed on T-cells and inhibits the PD-1- and LAG-3-mediated downregulation of T-cell activation and proliferation. This may lead to cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells. PD-1 and LAG-3 play key roles in suppressing T-cell activation and proliferation. |
| FULL_SYN |
EMB02 EMB 02 Anti-PD-1/LAG-3 Bispecific Antibody EMB-02 EMB-02 |
| Has_Target | |
| label |
Anti-PD-1/LAG-3 Bispecific Antibody EMB-02 |
| NCI_Drug_Dictionary_ID |
804662 |
| NCI_META_CUI |
CL1661932 |
| Preferred_Name |
Anti-PD-1/LAG-3 Bispecific Antibody EMB-02 |
| prefixIRI |
Thesaurus:C179258 |
| prefLabel |
Anti-PD-1/LAG-3 Bispecific Antibody EMB-02 |
| Semantic_Type |
Pharmacologic Substance |
| subClassOf |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C134305 |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| There are currently no mappings for this class. | |||